Down-regulated and Commonly mutated ALPK1 in Lung and Colorectal Cancers

Down-regulated and Commonly mutated ALPK1 in Lung and Colorectal Cancers

The ALPK1 gene located in the 4q25 region encodes a newly explored protein kinase which could phosphorylate the amino acid of a domain full of α-helices. Recently, several studies have indicated that the expression of ALPK1 is related to inflammation and various diseases; therefore, the purpose of this investigation was to determine whether the expression of ALPK1 has an influence on tumorigene...

Molecular understanding of KRAS- and BRAF-mutated colorectal cancers

epidemiological study of oral and pharyngeal cancers in kermanshah province from march 1993 to march 2006

چکیده ندارد.

SOX7 is down-regulated in lung cancer

BACKGROUND SOX7 is a transcription factor belonging to the SOX family. Its role in lung cancer is unknown. METHODS In this study, whole genomic copy number analysis was performed on a series of non-small cell lung cancer (NSCLC) cell lines and samples from individuals with epidermal growth factor receptor (EGFR) mutations using a SNP-Chip platform. SOX7 was measured in NSCLC samples and cell ...

Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers

Colorectal cancer (CRC) is a heterogeneous disease with multiple underlying causative genetic mutations. Genetic mutations in the phosphatidylinositol-3 kinase (PI3K) and the mitogen activated protein kinase (MAPK) pathways are frequently implicated in CRC. Targeting the downstream substrate MEK in these mutated tumors stands out as a potential target in CRC. Several selective inhibitors of MEK...